Fentiman I S
Ann R Coll Surg Engl. 1980 Jul;62(4):280-6.
Direct intercellular communication is the transfer of ions and small molecules between cells in contact. Cells derived from human breast tissue have been examined to determine their pattern of direct communication, which was measured by the 3H-uridine nucleotide transfer method. The behaviour of mammary epithelium from normal and pathological sources has been compared with that of malignant mammary epithelium. Normal human mammary fibroblasts and epithelium demonstrate selectivity in direct communication. Thus although both transfer nucleotide to and from their own cell type, they do not transfer nucleotide between one another in heterologous co-culture. Further study of a variety of non-human fibroblasts and epithelium showed that cells may be functionally subdivided into selective communicators, non-selective communicators, and non-communicators. None of the malignant human breast cells examined showed selectivity in communication. Thus both primary cultures and established lines were either non-communicators or non-selective communicators. This loss of selectivity could favour the metastasis of malignant cells, enabling them either to ignore inhibitory growth control signals or alternatively to receive stimulatory signals from abnormal sources.
直接细胞间通讯是指相互接触的细胞之间离子和小分子的传递。研究人员对源自人类乳腺组织的细胞进行了检测，以确定其直接通讯模式，该模式通过³H-尿苷核苷酸转移法进行测定。已将正常和病理来源的乳腺上皮细胞的行为与恶性乳腺上皮细胞的行为进行了比较。正常人类乳腺成纤维细胞和上皮细胞在直接通讯中表现出选择性。因此，尽管它们都能与自身细胞类型相互转移核苷酸，但在异种共培养中它们不会相互转移核苷酸。对多种非人类成纤维细胞和上皮细胞的进一步研究表明，细胞在功能上可细分为选择性通讯细胞、非选择性通讯细胞和非通讯细胞。所检测的恶性人类乳腺细胞均未表现出通讯选择性。因此，原代培养物和已建立的细胞系要么是非通讯细胞，要么是非选择性通讯细胞。这种选择性的丧失可能有利于恶性细胞的转移，使它们要么忽略抑制生长的控制信号，要么从异常来源接收刺激信号。
