Tsuchiya K, Sugita M, Sakurai H
Sangyo Igaku. 1978 Sep;20(5):247-53.
In this study dose-response and dose-effect relationships were examined with reference to no-effect levels using observed data from three groups of lead workers who had been exposed to three different concentrations of lead. Blood lead concentration (PbB) was used for "dose" and ALA concentration in urine (ALAU) and rate for 5 mg/l or greater of ALAU were used as "effect" and "response" respectively. Dose-effect and dose-response relationships between PbB and ALAU of these three different exposure populations indicated three different curves although theoretically they should all have indicated a similar curve. This means that "effect" or "response" for the highest exposure group was higher than that for the lowest exposure group on the same "dose" level. This difference is statistically explained for the most part by variations in the determinations of "dose" (PbB) as well as "effect" or "response" (ALAU). In view of the above results, it would seem that re-examination is required in establishing criteria of no-effect levels for dose-response relationships of various environmental chemicals.
在本研究中，参考无效应水平，利用三组接触三种不同浓度铅的铅作业工人的观察数据，研究了剂量-反应关系和剂量-效应关系。血铅浓度（PbB）用作“剂量”，尿中δ-氨基乙酰丙酸浓度（ALAU）以及尿中ALAU浓度为5mg/l或更高的比例分别用作“效应”和“反应”。这三个不同暴露人群的PbB与ALAU之间的剂量-效应和剂量-反应关系显示出三条不同的曲线，尽管从理论上讲它们都应显示出相似的曲线。这意味着在相同的“剂量”水平上，最高暴露组的“效应”或“反应”高于最低暴露组。这种差异在很大程度上从统计学上解释为“剂量”（PbB）以及“效应”或“反应”（ALAU）测定中的变化。鉴于上述结果，在确定各种环境化学品剂量-反应关系的无效应水平标准时，似乎需要重新审视。
