Torres A, Martinez F, Gómez P, Gómez C, Garcia J M, Nuñez-Roldan A
Cancer. 1980 Aug 15;46(4):838-43. doi: 10.1002/1097-0142(19800815)46:4<838::aid-cncr2820460433>3.0.co;2-y.
We report 3 cases of Hodgkin's disease (HD) within a family of seven children. All three children had mixed cellularity type in different stages of the disease (IV-B, III-A, and II-A). The diagnosis was made within a one-month interval. HLA typing shows an identical genotype in the 3 HD patients, which was different from the rest of the family. One of the patients developed an idiopathic thrombocytopenic purpura (ITP) with temporary response to prednisone and MOPP-C chemotherapy that subsided after splenectomy. The HLA identity, in addition to the simultaneous onset of the HD, suggests a combination of both genetic and environmental factors in the pathogenesis of this disease.
我们报告了一个有七个孩子的家庭中有3例霍奇金病（HD）患者。所有三个孩子患的都是混合细胞型，处于疾病的不同阶段（IV - B期、III - A期和II - A期）。诊断在一个月内完成。HLA分型显示，这3例HD患者具有相同的基因型，与家族中的其他成员不同。其中一名患者出现了特发性血小板减少性紫癜（ITP），对泼尼松和MOPP - C化疗有短暂反应，脾切除术后症状缓解。HLA相同，再加上HD同时发病，提示在该疾病的发病机制中遗传和环境因素都有作用。
