Brandt G, Spitzer F
Leber Magen Darm. 1978 Dec;8(6):343-6.
Concentrations of iron, copper and zinc were measured in postmortem specimens of liver, muscle and brain tissue by atomic absorption spectrophotometry. Concentrations varied markedly in normal liver specimens from person to person, but not in other organ specimens. Copper concentrations in specimens from cirrhotic livers were normal in most cases, however at the upper limit of normal in about 20% of the cases evaluated. Concentrations of zinc and iron were lower than normal in cirrhotic livers. Mineral concentrations were higher by a factor of 10-20 in liver specimens of patients with hemochromatosis or M. Wilson than in normals. Iron overloading as a consequence of therapy (secondary hemochromatosis) and liver changes due to longtime artificially elevated plasma copper levels may imitate the adult form of the "classic" mineral storage diseases mentioned. Thus "athrocytotic" liver cirrhosis, being caused or accompanied by metal excess has to be considered as a polyetiological syndrome.
采用原子吸收分光光度法测定了肝脏、肌肉和脑组织的死后标本中铁、铜和锌的浓度。正常肝脏标本中的浓度在个体之间差异显著，但在其他器官标本中并非如此。大多数情况下，肝硬化肝脏标本中的铜浓度正常，但在约20%接受评估的病例中处于正常上限。肝硬化肝脏中锌和铁的浓度低于正常水平。血色素沉着症或威尔逊病患者肝脏标本中的矿物质浓度比正常人高10至20倍。治疗导致的铁过载（继发性血色素沉着症）以及长期人为升高血浆铜水平引起的肝脏变化可能会模仿上述“经典”矿物质储存疾病的成人形式。因此，由金属过量引起或伴有金属过量的“含铁血黄素沉着性”肝硬化必须被视为一种多病因综合征。
