催乳素在吲哚美辛处理的大鼠中维持假孕状态。

Maintenance of pseudopregnancy by prolactin in indomethacin treated rats.

Tan G J

Clin Exp Pharmacol Physiol. 1980 May-Jun;7(3):335-8. doi: 10.1111/j.1440-1681.1980.tb00079.x.

Abstract

The effects of bromocriptine and indomethacin on prolactin-induced pseudopregnancy were studied in pituitary grafted rats. 2.Administration of bromocriptine (a prolactin suppressant drug) at a total dose of 3 mg/kg body weight, given in 3 divided doses on day 5 of pseudopregnancy, effectively terminated it within 3 days. However, injection of indomethacin (a prostaglandin inhibitor) at a total dose of 6 mg/kg body weight, given in 3 divided doses, on the same day of pseudopregnancy had no significant effect on its duration. 3. It appears unlikely that the luteotrophic effect of prolactin on the corpus luteum is mediated by the stimulation of prostaglandin synthesis.

摘要

在垂体移植大鼠中研究了溴隐亭和吲哚美辛对催乳素诱导的假孕的影响。2. 在假孕第5天以3 mg/kg体重的总剂量、分3次给予溴隐亭（一种催乳素抑制药物），能在3天内有效终止假孕。然而，在假孕当天以6 mg/kg体重的总剂量、分3次注射吲哚美辛（一种前列腺素抑制剂），对假孕持续时间没有显著影响。3. 催乳素对黄体的促黄体作用似乎不太可能是通过刺激前列腺素合成来介导的。