Dvorchik B H, Katlic K L, Hayes A H, Eyster M E
Clin Pharmacol Ther. 1980 Aug;28(2):223-8. doi: 10.1038/clpt.1980.154.
Healthy male subjects received, 1 wk apart, single oral doses of epsilon-aminocaproic acid (EACA) 100 mg/kg alone, EACA within probenecid (0.5 gm), or EACA 2 hr after 2.0 gm probenecid. Probenecid (2.0 gm) reduced the 8-hr urinary clearance and recovery of EACA by 50% without affecting plasma kinetics. Recovery of EACA in urine rose to 78% of the dose 48 hr after EACA. Plasma clearance of EACA did not differ from control EACA urinary clearance when 0.5 gm probenecid was given with EACA. In both cases all the EACA dose was recovered in urine within 8 hr.
健康男性受试者每隔1周接受单次口服剂量的ε-氨基己酸（EACA），剂量为100mg/kg，单独使用，或与丙磺舒（0.5g）一起使用EACA，或在服用2.0g丙磺舒2小时后使用EACA。丙磺舒（2.0g）使EACA的8小时尿清除率和回收率降低了50%，而不影响血浆动力学。EACA给药48小时后，尿中EACA的回收率升至剂量的78%。当EACA与0.5g丙磺舒一起给药时，EACA的血浆清除率与对照EACA的尿清除率无差异。在这两种情况下，所有EACA剂量在8小时内都在尿中回收。
