甲状旁腺激素对肾小球功能的影响。

Effects of parathyroid hormone on glomerular function.

作者信息

Ichikawa I, Brenner B M

出版信息

Contrib Nephrol. 1980;20:38-45. doi: 10.1159/000384952.

Abstract

Acute thyroparathyroidectomy (TPTX) in rats results in a marked increase in the glomerular capillary ultrafiltration coefficient, Kf. Infusion of a submaximal dose of bovine PTH (1 U/kg/min) returns Kf to non-TPTX levels. Infusion of 10 U/kg/min of bovine PTH further reduces Kf and leads to a net reduction in single nephron GFR. These findings suggest that PTH may play an important role in modulating Kf and, consequently, GFR.

摘要

大鼠急性甲状旁腺切除术（TPTX）会导致肾小球毛细血管超滤系数Kf显著增加。输注亚最大剂量的牛甲状旁腺激素（PTH，1 U/kg/分钟）可使Kf恢复到未进行TPTX时的水平。输注10 U/kg/分钟的牛PTH会进一步降低Kf，并导致单个肾单位肾小球滤过率（GFR）净降低。这些发现表明，PTH可能在调节Kf以及由此调节GFR方面发挥重要作用。