Guindi S, Mansour M M, Girgis N I, Miner W F
Eur Neurol. 1980;19(4):247-51. doi: 10.1159/000115154.
Serum and CSF protein electrophoresis was performed on cellulose acetate in 8 controls and 30 cases of tuberculous meningitis before treatment and during a hospitalization period of 5 months. The analysis of the CSF electrophoretic pattern showed that abnormalities in the prealbumin, beta and gamma fractions may still exist as late as 5 months after initiation of treatment. An increase in alpha 2 and decrease in the albumin fractions in the serum also persisted. Treatment for 20 weeks improved the clinical condition of the patients and resulted in a significant improvement in the CSF prealbumin and alpha 1 fractions. These findings indicate that changes in these fractions may be considered a good prognostic aid.
对8名对照者以及30例结核性脑膜炎患者在治疗前及住院5个月期间进行了血清和脑脊液蛋白电泳，采用醋酸纤维素法。脑脊液电泳图谱分析显示，治疗开始后长达5个月，前白蛋白、β和γ组分仍可能存在异常。血清中α2组分增加而白蛋白组分减少的情况也持续存在。治疗20周改善了患者的临床状况，并使脑脊液前白蛋白和α1组分有显著改善。这些发现表明，这些组分的变化可被视为良好的预后指标。
