Kangas L, Erkkola R, Kanto J, Eronen M
Eur J Clin Pharmacol. 1980 Apr;17(4):301-4. doi: 10.1007/BF00625804.
Six women, 13 to 16 weeks pregnant, and 12 women at 38 to 40 weeks gestation, received oral oxazepam about 12 h before legal abortion, by hysterotomy in the former and before elective caesarean section in the latter group. The concentrations of free and conjugated oxazepam in maternal and fetal plasma were determined by gas-liquid chromatography. In early pregnancy the mean ratio between the plasma concentration of total (free + conjugated) drug in the umbilical cord and a maternal vein was 0.6 whereas in late preganancy the ratio vein was 1.1. Both in early and late pregnancy, the free and glucuronide conjugate of oxazepam were found in the fetus at concentrations which indicated transplacental passage of the parent drug and its metabolite. There was great interindividual variation in the plasma levels both of free and conjugated oxazepam.
6名怀孕13至16周的女性和12名怀孕38至40周的女性,在合法堕胎前约12小时口服奥沙西泮,前者通过子宫切开术堕胎,后者在择期剖宫产术前服用。通过气液色谱法测定母体和胎儿血浆中游离和结合型奥沙西泮的浓度。在妊娠早期,脐带血中总(游离+结合)药物的血浆浓度与母体外周静脉血中该浓度的平均比值为0.6,而在妊娠晚期该比值为1.1。在妊娠早期和晚期,均可在胎儿体内发现奥沙西泮的游离型和葡萄糖醛酸结合物,其浓度表明母体药物及其代谢产物可经胎盘转运。游离和结合型奥沙西泮的血浆水平存在很大的个体差异。