麦角新碱对离体犬冠状动脉的作用方式

On the mode of action of ergometrine in the isolated dog coronary artery.

作者信息

Sakanashi M, Yonemura K I

出版信息

Eur J Pharmacol. 1980 Jun 13;64(2-3):157-60. doi: 10.1016/0014-2999(80)90038-2.

Abstract

Coronary vasoconstrictor responses to ergometrine were examined in spiral coronary arterial preparations of dogs. Either ergometrine or serotonin (5-HT) produced dose-dependent contractions of the strips. Methysergide significantly depressed the contractions induced by ergometrine or 5-Ht. Dihydroergotamine and phentolamine depressed constrictor responses to ergometrine, while phenoxybenzamine did not. The 5-HT antagonistic action of phentolamine was stronger than that of phenoxybenzamine. The results indicate that ergometrine may act on coronary arteries mainly through activation of 5-HT receptors.

摘要

在犬的螺旋冠状动脉制备物中研究了麦角新碱对冠状动脉的收缩反应。麦角新碱或5-羟色胺（5-HT）均可使血管条产生剂量依赖性收缩。甲基麦角新碱可显著抑制麦角新碱或5-羟色胺诱导的收缩。双氢麦角胺和酚妥拉明可抑制麦角新碱引起的收缩反应，而苯氧苄胺则无此作用。酚妥拉明的5-羟色胺拮抗作用强于苯氧苄胺。结果表明，麦角新碱可能主要通过激活5-羟色胺受体而作用于冠状动脉。