5-羟色胺对犬离体冠状动脉的作用。
Effects of 5-hydroxytryptamine on canine isolated coronary arteries.
作者信息
Porquet M F, Pourrias B, Santamaria R
出版信息
Br J Pharmacol. 1982 Feb;75(2):305-10. doi: 10.1111/j.1476-5381.1982.tb08787.x.
The effects of 5-hydroxytryptamine (5-HT) were studied in vitro on proximal and distal portions of canine interventricular and circumflex coronary arterial strips. 5-HT produced concentration-related contractions in the proximal portion whether contracted previously with KCl or not. These responses were still present after either chemical sympathetic denervation or release of noradrenaline induced by K+-free salt solution. In contrast, the distal portions of coronary arteries did not respond to 5-HT. Concentration-response curves to 5-HT exhibited a classical hyperbolic shape with a calculated Hill-coefficient of approximately 1. Methysergide and phentolamine but not morphine shifted to the right and depressed the maximum of the dose-response curves to 5-HT. It is concluded that the contractions produced by 5-HT in the proximal portion of the interventricular and circumflex coronary arteries are not due to the release of endogenous noradrenaline. The vessels appear to possess separate receptors for 5-HT and noradrenaline and the 5-HT responses belong to neither the M nor the D type.
研究了5-羟色胺（5-HT）对犬心室间冠状动脉和回旋冠状动脉条近端和远端的体外作用。无论之前是否用氯化钾收缩过，5-HT在近端均产生浓度相关的收缩。在化学性交感神经去神经支配或无钾盐溶液诱导去甲肾上腺素释放后，这些反应仍然存在。相比之下，冠状动脉远端对5-HT无反应。5-HT的浓度-反应曲线呈现典型的双曲线形状，计算得出的希尔系数约为1。麦角新碱和酚妥拉明可使5-HT的剂量-反应曲线右移并降低其最大值，而吗啡则无此作用。结论是，5-HT在心室间冠状动脉和回旋冠状动脉近端产生的收缩并非由于内源性去甲肾上腺素的释放。这些血管似乎具有5-HT和去甲肾上腺素的独立受体，且5-HT反应既不属于M型也不属于D型。
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