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Effects of 5-hydroxytryptamine on canine isolated coronary arteries.5-羟色胺对犬离体冠状动脉的作用。
Br J Pharmacol. 1982 Feb;75(2):305-10. doi: 10.1111/j.1476-5381.1982.tb08787.x.
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On the mode of action of ergometrine in the isolated dog coronary artery.麦角新碱对离体犬冠状动脉的作用方式
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Effects of U46619 on contractions to 5-HT, sumatriptan and methysergide in canine coronary artery and saphenous vein in vitro.U46619对犬冠状动脉和隐静脉体外5-羟色胺、舒马曲坦和甲基麦角新碱收缩作用的影响。
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Comparison of contractile responses to 5-hydroxytryptamine and sumatriptan in human isolated coronary artery: synergy with the thromboxane A2-receptor agonist, U46619.人离体冠状动脉对5-羟色胺和舒马曲坦收缩反应的比较：与血栓素A2受体激动剂U46619的协同作用。
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The mechanism of ergometrine-induced coronary arterial spasm: in vitro studies on canine arteries.麦角新碱诱导冠状动脉痉挛的机制：犬动脉的体外研究
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引用本文的文献

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Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors.育亨宾和萝芙辛通过阻断5-HT2受体抑制5-羟色胺诱导的小牛大冠状动脉收缩。
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本文引用的文献

1
RESPONSES OF CORONARY SMOOTH MUSCLE TO CATECHOLAMINES.冠状动脉平滑肌对儿茶酚胺的反应
Circ Res. 1965 May;16:431-40. doi: 10.1161/01.res.16.5.431.
2
Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.累积剂量-反应曲线。II. 离体器官中剂量-反应曲线的制作技术及药物参数的评估
Arch Int Pharmacodyn Ther. 1963;143:299-330.
3
Effect of the Ca2+ antagonist lidoflazine on normoxic and anoxic contractions of canine coronary arterial smooth muscle.钙离子拮抗剂利多氟嗪对犬冠状动脉平滑肌常氧和缺氧收缩的影响。
Eur J Pharmacol. 1980 Jun 13;64(2-3):173-6. doi: 10.1016/0014-2999(80)90042-4.
4
The mechanism of ergometrine-induced coronary arterial spasm: in vitro studies on canine arteries.麦角新碱诱导冠状动脉痉挛的机制：犬动脉的体外研究
J Cardiovasc Pharmacol. 1980 Sep-Oct;2(5):645-55. doi: 10.1097/00005344-198009000-00013.
5
On the mechanism of the coronary dilator effect of serotonin in the dog.关于血清素对犬冠状动脉扩张作用的机制
Eur J Pharmacol. 1976 Mar;36(1):1-5. doi: 10.1016/0014-2999(76)90249-1.
6
In vitro denervation of the portal vein and caudal artery of the rat.大鼠门静脉和尾动脉的体外去神经支配
J Pharmacol Exp Ther. 1976 Sep;198(3):568-77.
7
Tonic influence of the sympathetic nervous system on myocardial reactive hyperemia and on coronary blood flow distribution in dogs.
Circ Res. 1977 Jul;41(1):51-8. doi: 10.1161/01.res.41.1.51.
8
Pharmacological analysis of 5-hydroxytryptamine receptors in isolated intracranial and extracranial vessels of cat and man.猫和人离体颅内及颅外血管中5-羟色胺受体的药理学分析。
Circ Res. 1978 Jan;42(1):143-51. doi: 10.1161/01.res.42.1.143.
9
Distribution and characterization of the adrenoceptors in dog coronary arteries.犬冠状动脉中肾上腺素能受体的分布与特性
Arch Int Pharmacodyn Ther. 1979 Jun;239(2):195-207.

5-羟色胺对犬离体冠状动脉的作用。

Effects of 5-hydroxytryptamine on canine isolated coronary arteries.

作者信息

Porquet M F, Pourrias B, Santamaria R

出版信息

Br J Pharmacol. 1982 Feb;75(2):305-10. doi: 10.1111/j.1476-5381.1982.tb08787.x.

DOI:10.1111/j.1476-5381.1982.tb08787.x
PMID:7186819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071612/
Abstract

The effects of 5-hydroxytryptamine (5-HT) were studied in vitro on proximal and distal portions of canine interventricular and circumflex coronary arterial strips. 5-HT produced concentration-related contractions in the proximal portion whether contracted previously with KCl or not. These responses were still present after either chemical sympathetic denervation or release of noradrenaline induced by K+-free salt solution. In contrast, the distal portions of coronary arteries did not respond to 5-HT. Concentration-response curves to 5-HT exhibited a classical hyperbolic shape with a calculated Hill-coefficient of approximately 1. Methysergide and phentolamine but not morphine shifted to the right and depressed the maximum of the dose-response curves to 5-HT. It is concluded that the contractions produced by 5-HT in the proximal portion of the interventricular and circumflex coronary arteries are not due to the release of endogenous noradrenaline. The vessels appear to possess separate receptors for 5-HT and noradrenaline and the 5-HT responses belong to neither the M nor the D type.

摘要

研究了5-羟色胺（5-HT）对犬心室间冠状动脉和回旋冠状动脉条近端和远端的体外作用。无论之前是否用氯化钾收缩过，5-HT在近端均产生浓度相关的收缩。在化学性交感神经去神经支配或无钾盐溶液诱导去甲肾上腺素释放后，这些反应仍然存在。相比之下，冠状动脉远端对5-HT无反应。5-HT的浓度-反应曲线呈现典型的双曲线形状，计算得出的希尔系数约为1。麦角新碱和酚妥拉明可使5-HT的剂量-反应曲线右移并降低其最大值，而吗啡则无此作用。结论是，5-HT在心室间冠状动脉和回旋冠状动脉近端产生的收缩并非由于内源性去甲肾上腺素的释放。这些血管似乎具有5-HT和去甲肾上腺素的独立受体，且5-HT反应既不属于M型也不属于D型。