[Covalent C-terminal hydrophilisation of cyanogen bromide peptides with arginine in the sequenator (author's transl)].

Cyanogen bromide peptides are modified with arginine (free base) at the C-terminal homoserin lactone. This modification makes the peptides more hydrophilic. In that way the degradation is possible up to homoserine and the C-terminal arginine. The phenylthiohydantoin derivatives of homoserine and arginine can be detected in good yields by thin-layer or high performance liquid chromatography. The automatic Edman degradation is investigated under various conditions.