Hershko C, Gaziel Y, Bar-Or D, Izak G, Naparstek E, Grossowicz N, Kaufman N, Konijn A M
Isr J Med Sci. 1980 May;16(5):384-8.
The prevalence and causes of anemia were studied in 294 Druze children aged 10 months to six years. The hemoglobin level was less than 11.0 g/dl in 19%; none of these anemic children had folate deficiency. Iron deficiency, diagnosed on the basis of abnormal values for at least two independent laboratory parameters, was the cause of anemia in all but two cases. The Pearson correlation coefficient for hemoglobin was highest with mean corpuscular volume, erythrocyte protoporphyrin, serum iron, transferrin saturation, total-iron-binding capacity, and serum ferritin. Mean corpuscular hemoglobin and transferrin saturation were abnormal in greater than 90% of anemic children, whereas serum ferritin and total-iron-binding capacity were abnormal in only 70%. In view of its limited sensitivity, serum ferritin appears to be a less useful diagnostic aid in iron-deficiency anemia than other, less expensive laboratory methods.
对294名年龄在10个月至6岁的德鲁兹儿童的贫血患病率及病因进行了研究。19%的儿童血红蛋白水平低于11.0 g/dl；这些贫血儿童中无一例有叶酸缺乏。除两例病例外，根据至少两项独立实验室参数的异常值诊断出的缺铁是所有贫血病例的病因。血红蛋白与平均红细胞体积、红细胞原卟啉、血清铁、转铁蛋白饱和度、总铁结合力和血清铁蛋白的皮尔逊相关系数最高。超过90%的贫血儿童平均红细胞血红蛋白和转铁蛋白饱和度异常，而血清铁蛋白和总铁结合力仅70%异常。鉴于其敏感性有限，血清铁蛋白在缺铁性贫血诊断中似乎不如其他成本较低的实验室方法有用。
