Snyder S
J Clin Psychiatry. 1980 Aug;41(8):286-9.
Substantial improvement in 2 patients with obsessive-compulsive neurosis resulted from the administration of amitriptyline. No other pharmacologic or psychologic intervention had previously been effective in these patients. This tricyclic antidepressant has a pharmacologic spectrum of action very similar to chlorimipramine. Both drugs cause significant impairment in serotonin (5-hydroxytryptamine) reuptake. Evidence for a relative deficit in the central availability of 5-hydroxytryptamine (5-HT) in obsessive-compulsive phenomena is presented and a rationale for the use of these agents evolves.
两位患有强迫性神经症的患者在服用阿米替林后有显著改善。此前，其他药物或心理干预对这些患者均无效。这种三环类抗抑郁药的药理作用谱与氯米帕明非常相似。两种药物都会导致血清素（5-羟色胺）再摄取显著受损。文中提出了在强迫现象中5-羟色胺（5-HT）中枢可用性相对不足的证据，并由此形成了使用这些药物的理论依据。
