Boyle V J
J Biomed Mater Res. 1980 Jul;14(4):487-97. doi: 10.1002/jbm.820140415.
The linear, crosslinked amylose-succinate hemostatic agent, IP760, has been evaluated for its interaction with aminoglycosidic antibiotics. The highly structured polymer appears to act as a cationic exchange resin which binds the basic aminoglycosides. Binding of these agents to IP760 is reversed by increased pH and/or increased ionic strength. Dialysis experiments demonstrated that 85 and 90% of the bound gentamicin was released at pH 7.5 and 8.0, respectively, over a period of 36 hr. Formation of the IP760-antibiotic complexes suggests potential medicinal use for hemostatis and slow release of the antibiotic for prophylaxis of postsurgical contamination or infection
线性交联直链淀粉琥珀酸酯止血剂IP760已针对其与氨基糖苷类抗生素的相互作用进行了评估。这种高度结构化的聚合物似乎起到阳离子交换树脂的作用，可结合碱性氨基糖苷类药物。这些药物与IP760的结合会因pH值升高和/或离子强度增加而逆转。透析实验表明，在36小时内，分别有85%和90%的结合庆大霉素在pH值为7.5和8.0时被释放。IP760-抗生素复合物的形成表明其在止血以及抗生素缓释以预防术后污染或感染方面具有潜在的药用价值。
