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两种商用牛血管异种移植物的评估(作者译)

[Evaluation of two commercial bovine vascular heterografts (author's transl)].

作者信息

Paré G, Guidoin R, Marois M, Martin L, Gosselin C, Blais P, Laroche F, Noël H P, Roy P

出版信息

J Chir (Paris). 1980 May;117(5):331-9.

PMID:7400255
Abstract

Two commercially available grafts made from chemically modified bovine carotif arteries, Artegraft (Surgikos Corp. U.S.A.) and Solcograft (Solco A.G. Switzerland), were evaluated. Preliminary evaluation indicates that these products compare favorably with other more common chemically treated grafts of biological origin. Morphological characteristics, inflammatory response and thrombogenic potential were measured. Their structure suggest that each of the processes conserve the collagen morphology of the media and the adventitia originally present in the precursor arteries. Test implantations in dogs reveal a tendency to undergo stenosis near the anastomoses within a few months. After six months of in-vivo function, these grafts are not invaded with the expected neo-formed cells and new collagen in their central portion; this process takes place only near the anastomoses.

摘要

对两种市售的由化学改性牛颈动脉制成的移植物进行了评估,即美国 Surgikos 公司的 Artegraft 和瑞士 Solco A.G. 公司的 Solcograft。初步评估表明,这些产品与其他更常见的化学处理生物源移植物相比具有优势。测量了其形态特征、炎症反应和血栓形成潜力。它们的结构表明,每个过程都保留了前体动脉中原本存在的中膜和外膜的胶原形态。在狗身上进行的测试植入显示,几个月内吻合口附近有发生狭窄的趋势。经过六个月的体内功能测试后,这些移植物的中心部分并未如预期那样被新形成的细胞和新胶原侵入;这个过程仅在吻合口附近发生。

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