血清多巴胺-β-羟化酶活性与甲状腺功能之间的负相关关系。

The inverse relationship between serum dopamine-beta-hydroxylase activity and thyroid function.

作者信息

Stolk J M, Hurst J H, Nisula B C

出版信息

J Clin Endocrinol Metab. 1980 Aug;51(2):259-64. doi: 10.1210/jcem-51-2-259.

Abstract

Serum dopamine-beta-hydroxylase (DBH) activity is inversely related to thyroid status in both humans and rats. The low level of serum DBH activity in hyperthyroid rats is accompanied by a rapid rate of disappearance of enzyme activity after the injection of exogenous bovine DBH. Conversely, the high level of serum DBH activity in hypothyroid rats is accompanied by a slow rate of exogenous DBH disappearance. These results suggest that the extraneuronal disposal pathway for DBH is an important factor in the regulation of the level of DBH activity in altered thyroid function in both humans and rats.

摘要

血清多巴胺-β-羟化酶（DBH）活性在人类和大鼠中均与甲状腺状态呈负相关。甲状腺功能亢进大鼠的血清DBH活性水平较低，在注射外源性牛DBH后，酶活性的消失速度很快。相反，甲状腺功能减退大鼠的血清DBH活性水平较高，外源性DBH的消失速度较慢。这些结果表明，DBH的细胞外处理途径是调节人类和大鼠甲状腺功能改变时DBH活性水平的一个重要因素。