Laurian L, Oberman Z, Kisch E, Fitermann A
J Neural Transm. 1982;53(2-3):127-32. doi: 10.1007/BF01243404.
Twenty-seven healthy subjects, eight with high levels, eight with low levels and eleven with intermediate levels of serum dopamine-beta-hydroxylase (DBH) activity, were investigated. Serum DBH activity and blood pressure were measured in their response to the cold pressure test (CPT). Plasma renin activity (PRA) was also estimated. Blood pressure, systolic and dyastolic, increased equally in the three groups. PRA did not change significantly throughout the test in any of the groups. Serum DBH activity increased significantly in the group with low initial levels. No significant changes were seen in the controls and in the group with high initial serum DBH activity. It is suggested that subjects with high basal serum DBH activity might have a genetically-determined high sympathetic tone and therefore would hardly respond to a mild stress like CPT; the opposite might be true for the subjects with low basal DBH activity levels.
对27名健康受试者进行了研究，其中8名血清多巴胺-β-羟化酶（DBH）活性高，8名活性低，11名活性中等。测量了他们在冷压试验（CPT）中的血清DBH活性和血压。还估计了血浆肾素活性（PRA）。三组的收缩压和舒张压升高程度相同。在任何一组中，整个试验过程中PRA均无显著变化。初始水平低的组中血清DBH活性显著增加。对照组和初始血清DBH活性高的组中未见显著变化。提示基础血清DBH活性高的受试者可能具有遗传决定的高交感神经张力，因此对CPT这样的轻度应激几乎无反应；基础DBH活性水平低的受试者可能情况相反。
