Francis B M, Hansen L G, Metcalf R L
J Environ Sci Health B. 1980;15(4):313-31. doi: 10.1080/03601238009372186.
Twenty-seven halogenated organophosphorus esters were tested for neurotoxicity in adult hens. Fourteen compounds were overtly neurotoxic, including eight of the eleven methylphosphonothioates, three of seven ethylphosphonothioates, and three of six phosphoramidates, one of which was the commercial herbicide DMPA. Neurotoxic activity varied both with the number of halogen substituents on the phenyl group, and with the identity of the 4-phenyl halogen. Neurotoxic activity also varied with the alkyl group involved in the P-C or P-N bond, and with the identity of the O-alkyl group.
对27种卤代有机磷酸酯进行了成年母鸡神经毒性测试。14种化合物具有明显的神经毒性，包括11种甲基硫代膦酸酯中的8种、7种乙基硫代膦酸酯中的3种以及6种磷酰胺酯中的3种，其中一种是商用除草剂DMPA。神经毒性活性既随苯基上卤代取代基的数量变化，也随4-苯基卤的种类变化。神经毒性活性还随P-C或P-N键中涉及的烷基以及O-烷基的种类变化。
