Kibe A, Nakai S, Kuramoto T, Hoshita T
J Lipid Res. 1980 Jul;21(5):594-9.
Considerable amounts (6.0 mumol/ml of bile) of bile alcohols were found in the bile of a patient with cholestasis due to gallstones in a common bile duct. Acid hydrolysis of the bile salts followed by chromatographic separation yielded three bile alcohols, which were identified as 26,27-dinor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25-pentol, 24-methyl-26,-27-dinor-5 beta-cholestane-3 alpha,7 alpha, 24-tetrol, and 3 alpha,7 alpha, 12 alpha-trihydroxy-26,27-dinor-5 beta-cholestan-24-one by comparison with synthetic reference standards.
在一名因胆总管胆结石导致胆汁淤积的患者胆汁中发现了大量（6.0微摩尔/毫升胆汁）的胆汁醇。胆汁盐经酸水解后进行色谱分离，得到三种胆汁醇，通过与合成参考标准品比较，鉴定为26,27 - 二降 - 5β - 胆甾烷 - 3α,7α,12α,24,25 - 戊醇、24 - 甲基 - 26, - 27 - 二降 - 5β - 胆甾烷 - 3α,7α, 24 - 四醇和3α,7α, 12α - 三羟基 - 26,27 - 二降 - 5β - 胆甾烷 - 24 - 酮。
