McDougall I R, Bayer M F
J Nucl Med. 1980 Aug;21(8):741-4.
An immunoradiometric assay for thyroglobulin (Tg), which allows quantification of Tg in the presence of anti- Tg, has been evaluated in patients with differentiated thyroid cancer. All patients had undergone thyroidectomy plus I- 131 ablation. Three separate studies have been conducted. 1. Tg levels were compared with I- 131 whole-body scans made at 48 hr in 22 patient studies. Both tests gave similar results in 19 of the studies, but in three patients the results of the tests were discordant. 2. Tg levels were compared with clinical status in 18 patients who were free of disease; 15 had Tg values < 5 ng/ml, and three had measurable but normal Tg values. Three patients with metastatic disease had measurable Tg, and in two the values were above normal. 3. Sequential Tg measurements were made at intervals of 3 mo in 19 patients on thyroxine. Fifteen of these patients had identical results on two or more occasions.
一种用于甲状腺球蛋白（Tg）的免疫放射分析方法，该方法能够在存在抗Tg的情况下对Tg进行定量分析，已在分化型甲状腺癌患者中进行了评估。所有患者均接受了甲状腺切除术加碘-131消融治疗。共进行了三项独立研究。1. 在22例患者研究中，将Tg水平与48小时时进行的碘-131全身扫描结果进行比较。在19项研究中，两项检测结果相似，但在3例患者中，检测结果不一致。2. 将18例无疾病患者的Tg水平与临床状况进行比较；15例患者的Tg值<5 ng/ml，3例患者的Tg值可测量但正常。3例有转移疾病的患者Tg可测量，其中2例的值高于正常水平。3. 对19例服用甲状腺素的患者每隔3个月进行一次连续的Tg测量。其中15例患者在两次或更多次测量中结果相同。
