Kimura S, Furukawa Y, Wakasugi J, Ishihara Y, Nakayama A
J Nutr Sci Vitaminol (Tokyo). 1980;26(2):113-7. doi: 10.3177/jnsv.26.113.
The inhibition rate of L(-)pantothenate as an antagonist of D(+)pantothenate was discussed from the viewpoint of growth and lipid metabolism. The growth rate of mice given pantothenate-deficient diets containing L(-)pantothenate (300 mg per 100g diet) was markedly decreased, and such pantothenate-deficient symptoms as "spectacle eyes" appeared. However, it was recovered by the simultaneous addition of D(+)pantothenate. This result suggets that L(-)pantothenate is an antagonist of D(+)pantothenate. The same phenomenon was observed in a rat experiment. The growth of rats given L(-)pantothenate was extremely poor but recovered by the simultaneous addition of D(+)pantothenate. Its complete recovery was seen when the ratio of L(-)pantothenate to D(+)pantothenate reached 100:1. The same tendencies were observed in the liver levels of total lipid, total cholesterol and triglyceride, and also in the lipoperoxide values. This experiment suggests that the inhibition rate of L(-)pantothenate to D(+)pantothenate in animals is similar to that of DL-omega-methyl pantothenate.
从生长和脂质代谢的角度讨论了L(-)泛酸盐作为D(+)泛酸盐拮抗剂的抑制率。给缺乏泛酸盐的小鼠喂食含有L(-)泛酸盐（每100克饲料300毫克）的饲料，其生长速度明显下降，并出现了“眼镜眼”等泛酸盐缺乏症状。然而，通过同时添加D(+)泛酸盐可使其恢复。这一结果表明L(-)泛酸盐是D(+)泛酸盐的拮抗剂。在大鼠实验中也观察到了相同的现象。喂食L(-)泛酸盐的大鼠生长极差，但通过同时添加D(+)泛酸盐得以恢复。当L(-)泛酸盐与D(+)泛酸盐的比例达到100:1时，可实现完全恢复。在肝脏中总脂质、总胆固醇和甘油三酯的水平以及脂质过氧化物值方面也观察到了相同的趋势。该实验表明，L(-)泛酸盐对动物体内D(+)泛酸盐的抑制率与DL-ω-甲基泛酸盐的抑制率相似。
