Long-term effects of prenatal oestrogen treatment on genital morphology and reproductive function in the rat.

Prenatal exposure to RU 2858 (11 beta-methoxy-19-nor-17 alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol) alters the genital tract of rat offspring more markedly than does oestradiol which is bound to a specific plasma protein. The morphological changes observed in the male fetus are partly restored during infancy and maturity. The main effect of the treatment is seen in the female offspring and consists of alterations of the genital tract and of reproductive function.