Konopelski J P, Djerassi C, Raynaud J P
J Med Chem. 1980 Jul;23(7):722-6. doi: 10.1021/jm00181a004.
The syntheses of phenylselenium-substituted progesterone [21- (1) and 17 alpha-(phenylseleno)progesterone (2)] and testosterone [16 beta- (3) and 16 alpha-(phenylseleno)testosterone (4)] derivatives are described, along with data which help to establish the stereochemistry of the substituents in the testosterone molecules. Except for 21-(phenylseleno)-progesterone, the molecules exhibit greatly reduced receptor-binding capabilities.
描述了苯基硒取代的孕酮[21-(1)和17α-(苯基硒基)孕酮(2)]以及睾酮[16β-(3)和16α-(苯基硒基)睾酮(4)]衍生物的合成，以及有助于确定睾酮分子中取代基立体化学的数据。除了21-(苯基硒基)-孕酮外，这些分子的受体结合能力大大降低。
