Kendall A R, Pollack H M, Petersen R O, Stein B S
J Urol. 1980 Aug;124(2):269-73. doi: 10.1016/s0022-5347(17)55403-8.
Doctor Petersen confirmed our preoperative suspicion that this lesion might represent a benign proximal tubular adenoma. Tessler and associates found 5 such cases from July 1974 to January 1975 and reviewed all cases of renal carcinoma in their institution from 1952 through 1975. An additional 9 cases were discovered with none before 1964. One must ask if there is an increased incidence now occurring or are we just beginning to recognize this entity with increasing sophistication? The question also must arise whether with a high degree of suspicion a less radical operation is indicated. Certainly, the angiogram is the only possible preoperative tool that can arouse suspicion but this still is far from diagnostic. The spoke-wheel configuration of vessels, a homogeneous nephrogram similar to the normal parenchyma and sharp margination in the absence of marked increased vascular puddling may all be suggestive. In this older patient with a normal contralateral kidney total nephrectomy still is indicated because angiographic patterns are not pathognomonic. Conversely, in the rare younger individual with concomitant unrelated bilateral renal disease or in the solitary kidney with a polar lesion partial nephrectomy should be considered. Although some differential recognition may be possible by gross examination, such as the tan color, sharp demarcation, absence of hemorrhage or necrosis and so forth, it always has been our policy not to violate Gerota's fascia or to biopsy in the treatment of suspected renal carcinoma. Thus, until a specific preoperative diagnosis is possible nephrectomy continues to be the treatment of choice in the proximal tubular adenoma with so-called oncocytic features. Debate will continue in urologic, pathologic and radiologic circles on whether such an entity is universally benign and with increasing recognition only time will tell.
彼得森医生证实了我们术前的怀疑,即这个病变可能是一个良性近端肾小管腺瘤。 Tessler及其同事在1974年7月至1975年1月期间发现了5例此类病例,并回顾了他们机构在1952年至1975年间的所有肾癌病例。另外还发现了9例,1964年以前没有。人们不禁要问,现在发病率是否在上升,还是我们只是随着技术的日益成熟才开始认识到这个实体?这个问题也必然会出现,即高度怀疑时是否应采取不太激进的手术。当然,血管造影是唯一可能引起怀疑的术前检查手段,但这离诊断仍相去甚远。血管呈辐轮状分布、肾图与正常实质相似且边界清晰,同时没有明显的血管池增加,这些都可能具有提示意义。对于这位对侧肾脏正常的老年患者,仍然建议行全肾切除术,因为血管造影模式并不具有特征性。相反,对于罕见的患有无关双侧肾脏疾病的年轻个体或患有极性病变的孤立肾患者,应考虑行部分肾切除术。尽管通过大体检查可能有一些鉴别诊断,比如黄褐色、边界清晰、无出血或坏死等,但我们的一贯原则是,在疑似肾癌的治疗中不侵犯肾周筋膜或进行活检。因此,在能够进行术前明确诊断之前,对于具有所谓嗜酸性细胞特征的近端肾小管腺瘤,肾切除术仍然是首选的治疗方法。关于这样一个实体是否普遍良性,泌尿外科、病理科和放射科的争论还将继续,随着认识的增加,只有时间能给出答案。