Caldarola L, Badellino F, Canavese G, Volterrani P, Giani R
Minerva Chir. 1978;33(23-24):1727-44.
The results obtained in 153 patients suffering from advanced primary, residual, recurrent and metastatic cancers localized mainly in the cervico-cephalic district and in other sites (skin, extremities and pelvis, liver, thoracic wall, breast) in whom locoregional intraarterial chemotherapy was employed from 1967, are reported. In order of frequency, the commonest antiblastics used were Methotrexate, 5 FU, Vincristin and DITC. Long-term results show an average remission of 52% and mean survival of 11.4 months; these values are liable to wild fluctuations in relation to various factors such as site, development, state of regional lymph nodes, and any previous surgical, radiation or antiblastic therapy. Intraarterial treatment is found to have the best effect in cases of cancer which have not previously been subjected to any therapy at all, and which involve the cervico-cephalic districts, the liver and melanomas.
报告了1967年以来对153例主要位于头颈区及其他部位（皮肤、四肢和骨盆、肝脏、胸壁、乳腺）的晚期原发性、残留、复发和转移性癌症患者采用局部区域动脉内化疗的结果。按使用频率排序，最常用的抗有丝分裂药物是甲氨蝶呤、5-氟尿嘧啶、长春新碱和二氯甲基二乙胺。长期结果显示平均缓解率为52%，平均生存期为11.4个月；这些数值因部位、发展情况、区域淋巴结状态以及任何先前的手术、放疗或抗有丝分裂治疗等各种因素而有很大波动。发现动脉内治疗对以前未接受过任何治疗、累及头颈区、肝脏和黑色素瘤的癌症病例效果最佳。
