Roos P J, Malan A F, Woods D L, Millar R P, Heese H D
S Afr Med J. 1980 May 24;57(21):873-5.
Cord plasma cortisol concentrations were measured in 52 preterm infants and related to amniotic fluid infection as evidenced by positive bacterial cultures. The cortisol levels were significantly raised in the group with an infected intra-uterine environment (519 +/- 158 nm/l) compared with the non-infected group (325 +/- 134 nm/l). This effect was independent of length of gestation, duration of rupture of membranes, or duration of labour. Infants with fetal growth retardation had raised cortisol levels (555 +/- 207 nm/l), while maternal dexamethasone therapy suppressed the levels (197 +/- 76 nm/l). Only 2 infants developed hyaline membrane disease, and in both bacterial culture was negative and cord cortisol levels low (231 and 239 nm/l). It is suggested that amniotic fluid infection may play a role in reducing the incidence of hyaline membrane disease by increasing fetal cortisol production.
对52名早产儿的脐带血血浆皮质醇浓度进行了测量，并与羊水感染情况相关联，羊水感染通过细菌培养阳性得以证实。与未感染组（325±134nmol/L）相比，子宫内环境感染组的皮质醇水平显著升高（519±158nmol/L）。这种效应与孕周、胎膜破裂时间或产程无关。胎儿生长受限的婴儿皮质醇水平升高（555±207nmol/L），而母亲地塞米松治疗可使皮质醇水平降低（197±76nmol/L）。仅有2名婴儿发生透明膜病，且二者的细菌培养均为阴性，脐带血皮质醇水平较低（分别为231和239nmol/L）。有人提出，羊水感染可能通过增加胎儿皮质醇的产生，在降低透明膜病的发病率方面发挥作用。
