van Eeden A F
S Afr Med J. 1980 Feb 23;57(8):278-9.
A comparison study of the induction properties of the new propylene glycol formulation of etomidate (Hypnomidate) and methohexitone in 80 patients who underwent elective surgical procedures is reported. Both agents gave uniformly good inductions. Methohexitone induction was associated with an elevation in heart rate, but in the etomidate group no cardiovascular instability was seen. In both groups there was a 20-25% incidence of pain on injection, but this was almost exclusively confined to the patients who were injected through the dorsal vein of the hand rather than the antecubital vein. In only 1 patient in the etomidate group did slight involuntary movements occur, but 11 patients (28%) in the methohexitone group showed this side-effect.
本文报道了一项针对80例接受择期外科手术患者的对比研究，比较了依托咪酯新丙二醇制剂（Hypnomidate）和美索比妥的诱导特性。两种药物均能产生一致良好的诱导效果。美索比妥诱导与心率升高有关，但依托咪酯组未见心血管不稳定情况。两组均有20%-25%的患者在注射时有疼痛感，但这几乎仅局限于通过手背静脉而非肘前静脉注射的患者。依托咪酯组仅1例患者出现轻微不自主运动，而美索比妥组有11例患者（28%）出现了这种副作用。
