Tobler I, Borbély A A
Waking Sleeping. 1980 Apr-Jun;4(2):139-53.
The effect of Delta Sleep Inducing Peptide (DSIP) and arginine vasotocin (AVT) on motor activity and sleep was investigated in the rat. Motor activity was not significantly reduced during the 24 h following systemic DSIP administration (40-160 nmol/kg i.p.), nor were sleep and the power of the EEG delta-band significantly increased in the 2 hours following injection or infusion of DSIP into the lateral or third ventricle (7-24 nmol). Injection or infusion of AVT into the lateral or third ventricle (10(-15)-10(-19) mol) did not enhance sleep and the power of the EEG delta-band. Nevertheless, the following significant effects indicate an unspecified biological action of the peptides: Dark-time motor activity was reduced 1 and 2 days after DSIP administration (160 nmol/kg), and the activity in the first 4 h after injection (80 nmol/kg) was increased. In addition, the power in the delta-band was reduced after administration of DISP (7 nmol) and AVT (10(-17) mol) into the third ventricle. Thus exceedingly small doses of AVT seem to exert not only endocrine, but also electrophysiological effects. It is concluded that neither DSIP nor AVT qualify as a specific sleep-promoting substance.
研究了δ睡眠诱导肽（DSIP）和精氨酸血管催产素（AVT）对大鼠运动活动和睡眠的影响。腹腔注射DSIP（40 - 160 nmol/kg）后24小时内，运动活动没有显著降低；向侧脑室或第三脑室注射或输注DSIP（7 - 24 nmol）后2小时内，睡眠和脑电图δ波频段的功率也没有显著增加。向侧脑室或第三脑室注射或输注AVT（10(-15)-10(-19) mol）并没有增强睡眠和脑电图δ波频段的功率。然而，以下显著效应表明这些肽具有未明确的生物学作用：DSIP给药（160 nmol/kg）后1天和2天，夜间运动活动减少，注射后（80 nmol/kg）前4小时活动增加。此外，向第三脑室注射DISP（7 nmol）和AVT（10(-17) mol）后，δ波频段的功率降低。因此，极少量的AVT似乎不仅具有内分泌作用，还具有电生理作用。结论是，DSIP和AVT都不能被认定为特定的促睡眠物质。
