[地高辛与奎尼丁的相互作用]
[Interaction of digoxin and quinidine].
作者信息
Haustein K O, Oltmanns G
出版信息
Z Gesamte Inn Med. 1980 Feb 15;35(4):186-7.
PMID:7405308
Abstract
Plasma digoxin level and digoxin excretion were studied in 5 pat. suffering from cardiovascular diseases who had to be digitalized because of acute states of congestive heart failure. One of the patients took quinidine simultaneously. In the "quinidine" patient digoxin level was elevated to the 2--2.5 fold, as compared with "control" patients. Digoxin excretion of the "quinidine" patient was slightly increased. Following the results, a reduction in digoxin dosage to half of the dose is recommended.
摘要
对5例患有心血管疾病且因充血性心力衰竭急性发作而必须进行洋地黄化的患者进行了血浆地高辛水平和地高辛排泄的研究。其中1例患者同时服用了奎尼丁。与“对照”患者相比，“奎尼丁”患者的地高辛水平升高至2至2.5倍。“奎尼丁”患者的地高辛排泄略有增加。根据研究结果，建议将地高辛剂量减半。
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