Veenendaal G H, Woutersen-van Nijnanten F M, van Miert A S
Am J Vet Res. 1980 Apr;41(4):479-83.
Concentration-response curves obtained for contraction of goat rumen strips indicated that both bradykinin (BK) and serotonin (5-hydroxytryptamine creatinin sulphate; 5-HT) are potent agents. Sodium meclofenamate antagonized the smooth muscle-stimulating action of BK; the 5-HT blocking agents xylamidine and methysergide diminished the contractile effects of 5-HT. The results indicated that the antagonisms are noncompetitive in nature. In vivo, both BK and 5-HT caused a dose-dependent inhibition of the rumen contraction sequences. The BK was the more potent of the two compounds. This inhibition was probably due to an increase in ruminal smooth muscle tone, resulting in reflex inhibition of the normal cyclical contraction sequences. In conscious goats, BK induced tachycardia, whereas 5-HT produced only minor changes in heart rate. Treatment with sodium meclofenamate or phenylbutazone prevented the BK-induced inhibition of rumen motility. Treatment with the 5-HT blocking agents only partly reduced the 5-HT-induced effects.
对山羊瘤胃肌条收缩所获得的浓度-反应曲线表明，缓激肽（BK）和血清素（5-羟色胺硫酸肌酐；5-HT）都是强效剂。甲氯芬那酸钠拮抗BK的平滑肌刺激作用；5-HT阻断剂赛拉米定和甲基麦角新碱减弱了5-HT的收缩作用。结果表明，这些拮抗作用本质上是非竞争性的。在体内，BK和5-HT均引起瘤胃收缩序列的剂量依赖性抑制。BK是这两种化合物中更有效的一种。这种抑制可能是由于瘤胃平滑肌张力增加，导致对正常周期性收缩序列的反射性抑制。在清醒的山羊中，BK诱发心动过速，而5-HT仅引起心率轻微变化。用甲氯芬那酸钠或保泰松治疗可防止BK诱导的瘤胃运动抑制。用5-HT阻断剂治疗仅部分降低了5-HT诱导的效应。
