Klausner J S, Osborne C A, O'Leary T P, Gebhart R N, Griffith D P
Am J Vet Res. 1980 May;41(5):712-9.
Magnesium ammonium phosphate calculi developed in the urinary bladders and urethras of four of five offspring of Miniature Schnauzer parents with recurrent struvite urolithiasis. Calculi were detected by radiograhy when the dogs were 12 to 15 months old. Males and females were affected. A significant number of urease-producing staphylococci were identified in the urine of three of four dogs before urolith formation, and in one dog after urolith formation. The dogs were evaluated until they were 26 months old. Serum concentrations of calcium, phosphorus, and magnesium were inside usual limits throughout the study. Abnormalities that might predispose to urinary tract infection were not identified by radiography or necropsy studies. In one dog, bladder calculi recurred after surgical removal of multiple cystoliths. In another, urethral obstruction and acute generalized pyelonephritis induced a lethal uremic crisis. Gross and microscopic lesions, detected after necropsy of all dogs with uroliths, were typical of bacterial infection.
患有复发性鸟粪石尿石症的迷你雪纳瑞犬父母所生的五只后代中，有四只在膀胱和尿道中形成了磷酸镁铵结石。当这些犬12至15个月大时，通过X线摄影检测到结石。公犬和母犬均受影响。在四只犬中有三只在结石形成前，以及一只犬在结石形成后，其尿液中鉴定出大量产脲酶葡萄球菌。对这些犬进行评估直至26个月大。在整个研究过程中，血清钙、磷和镁浓度均在正常范围内。通过X线摄影或尸检研究未发现可能易患尿路感染的异常情况。在一只犬中，手术切除多个膀胱结石后膀胱结石复发。在另一只犬中，尿道梗阻和急性全身性肾盂肾炎引发了致命的尿毒症危机。对所有患有尿石症的犬进行尸检后发现，大体和微观病变均为典型的细菌感染。
