Pfeifer G, Tauberger G, Schulte am Esch J
Prakt Anaesth. 1978 Dec;13(6):495-501.
The effect of Etomidate on central sympathetic activity, respiration and circulation were studied in animals at rest and under asphyctic conditions. The doses used were 0.15, 0.3 and 0.6 milligrams/kilogram bodyweight. Injection of the drug into animals at rest caused excitation lasting for about 10 seconds and then lowering of sympathetic activity by about 15-30 per cent. With doses of 0.6 mg the depression lasted for about 15 minutes. Central stimulation by asphyxia often a more pronounced dose-dependent depression of sympathetic activity by about 15-40% of the original level was observed. Activity of the phrenic nerve was affected only with doses of 0.6 mg; the reduction by about 30% lasted for up to 15 min. Injection of 0.6 mg was followed within one minute by a short-lasting fall in blood pressure by about 10%. The heart rate remained unchanged at rest but during asphyctic conditions the heart rate was less slowed down than would normally occur with vagal stimulation. Etomidate apparently also depressed the vagal centres. Similarities and differences in action between Etomidate and propanidid are discussed.
在静息和窒息状态的动物身上研究了依托咪酯对中枢交感神经活动、呼吸和循环的影响。所用剂量为0.15、0.3和0.6毫克/千克体重。给静息状态的动物注射该药物会引起持续约10秒的兴奋，随后交感神经活动降低约15%-30%。使用0.6毫克剂量时，抑制作用持续约15分钟。窒息引起的中枢刺激常观察到更明显的剂量依赖性交感神经活动抑制，降至原始水平的约15%-40%。仅在使用0.6毫克剂量时，膈神经活动受到影响；降低约30%持续长达15分钟。注射0.6毫克后一分钟内，血压短暂下降约10%。静息时心率保持不变，但在窒息状态下，心率减慢程度比正常迷走神经刺激时要小。依托咪酯显然也抑制了迷走神经中枢。讨论了依托咪酯和丙泮尼地在作用上的异同。
