Hatem J, Sade R M, Upshur J K, Hohn A R
Ann Surg. 1980 Jul;192(1):124-8. doi: 10.1097/00000658-198007000-00022.
We have used two methods to maintain ductal ppatency in 13 newborns during surgery for congenital cardiac malformations: prostaglandin E1 (PGE1) infusion for the short-term and formaldehyde infiltration of the ductus arteriosuos (FID) for the longer term. PGE1 increased the arterial oxygen saturation, leading to stable intraoperative hemodynamics in the six infants in whom it was used. FID was used in all 13 patients. Four of these patients died in the hospital, all with the ductus open. Of the nine early survivors, all required an additional shunt procedure. The five long-term survivors had the second palliative operation immediately, three hours, three days, two and one-half months, and four and one-half months after FID. We continue to use PGE1 to maintain ductal atency through operation, but use aortopulmonary anastomosis in the newborn period rather than FID.
我们采用了两种方法在13例先天性心脏畸形手术的新生儿中维持动脉导管通畅：短期使用前列腺素E1（PGE1）输注，长期使用动脉导管甲醛浸润（FID）。PGE1提高了动脉血氧饱和度，使使用该药物的6例婴儿术中血流动力学稳定。13例患者均使用了FID。其中4例患者在医院死亡，均为动脉导管未闭。9例早期存活者均需要再次进行分流手术。5例长期存活者在FID后立即、3小时、3天、2个半月和4个半月进行了第二次姑息性手术。我们继续使用PGE1在手术过程中维持动脉导管通畅，但在新生儿期采用主动脉-肺动脉吻合术而非FID。
