Starling M B, Neutze J M, Elliott R L, Taylor I M, Elliott R B
Prostaglandins Med. 1978 Oct;1(4):267-81. doi: 10.1016/0161-4630(78)90046-0.
Three methylated analogues of prostaglandin E1 and E2 were examined for their ability to open the ductus arterious of neonatal piglets in vivo. Fifteen (S) 15 methyl prostaglandin E1 (15-Me PGE1), 15 (S) 1K methyl prostaglandin E2 (15-Me PGE2), and 16' 16' dimethyl prostaglandin E1 (16-diMe PGE1) all opened the ductus when given intravenously, intramuscularly or orally. The effects on ductal patency lasted four hours or more in many instances. Side-effects included apnea with intravenous and intramuscular dosages, and with high oral dosages of 15-Me PGE1. A transient drop in heart rate and blood pressure occurred with each dose. In one animal the ductus was kept open for 19 days with six-hourly intramuscular injections of 3 microgram/kg 15-Me PGE1. Transient sedation occurred with each dose. Death occurred on the 19th day and histological studies showed that the morphology of the ductus wall was similar to that seen in a two day old animal. These studies suggest that maintenance od ductal patency in the infant may be possible with oral administration of methyl prostaglandin derivatives.
研究了前列腺素E1和E2的三种甲基化类似物在体内打开新生仔猪动脉导管的能力。十五（S）-15-甲基前列腺素E1（15-Me PGE1）、十五（S）-15-甲基前列腺素E2（15-Me PGE2）和16′，16′-二甲基前列腺素E1（16-二甲基PGE1）静脉内、肌内或口服给药时均能打开动脉导管。在许多情况下，对导管通畅的影响持续4小时或更长时间。副作用包括静脉内和肌内给药以及15-Me PGE1高口服剂量时出现呼吸暂停。每次给药后心率和血压都会短暂下降。在一只动物中，通过每6小时肌内注射3微克/千克的15-Me PGE1，动脉导管保持开放19天。每次给药后都会出现短暂的镇静作用。该动物在第19天死亡，组织学研究表明，动脉导管壁的形态与2日龄动物相似。这些研究表明，口服甲基前列腺素衍生物可能维持婴儿动脉导管的通畅。
