[异丙肾上腺素对自发性遗传性高血压大鼠脂肪细胞中腺苷酸环化酶活性的影响]
[Effect of isoproterenol on adenylate cyclase activity in the adipocytes of rats with spontaneous genetic hypertension].
作者信息
Reznikova M B, Postnov Iu V
出版信息
Biull Eksp Biol Med. 1980 Aug;90(8):182-4.
No differences were found in basal and NaF-stimulated activity of adipocyte adenylate cyclase in intact and adrenalectomized rats with normal blood pressure, as well as in intact and adrenalectomized spontaneously hypertensive rats (SHR). Vmax for isoproterenol-stimulated adenylate cyclase in normotensive and hypertensive rats was similar but Ka of the enzyme in SHR was 3 times higher than in control. Vmax of adrenalectomized rats with normal blood pressure was lowered by 27%, while in SHR adipocytes it was similar to Vmax in intact animals. A conclusion is made about the decreased sensitivity of SHR adipocyte adenylate cyclase to isoproterenol. The role of glucocorticoids in the regulation of enzymatic activity is discussed.
在血压正常的完整大鼠和肾上腺切除大鼠以及完整和肾上腺切除的自发性高血压大鼠（SHR）中，未发现脂肪细胞腺苷酸环化酶的基础活性和氟化钠刺激的活性有差异。正常血压和高血压大鼠中异丙肾上腺素刺激的腺苷酸环化酶的Vmax相似，但SHR中该酶的Ka比对照高3倍。血压正常的肾上腺切除大鼠的Vmax降低了27%，而在SHR脂肪细胞中，它与完整动物的Vmax相似。得出关于SHR脂肪细胞腺苷酸环化酶对异丙肾上腺素敏感性降低的结论。讨论了糖皮质激素在酶活性调节中的作用。
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