Wijnen H J, De Kloet E R, Versteeg D H, De Jong W
Brain Res. 1980 Oct 6;198(2):411-17. doi: 10.1016/0006-8993(80)90754-4.
The noradrenaline concentration and the alpha-methyl-para-tyrosine (alpha-MPT)-induced disappearance of noradrenaline were determined in several nuclei of the hypothalamus and the medulla oblongata of renal hypertensive rats (two-kidney Goldblatt hypertension). A decreased alpha-MPT-induced disappearance of noradrenaline was found in the nucleus interstitialis striae terminalis and the nucleus paraventricularis 3 days after renal artery constriction, when blood pressure was slightly, but significantly higher than that of sham operated rats. At this stage the alpha-MPT-induced disappearance of noradrenaline was enhanced in the nucleus commissuralis and the A1-region of hypertensive rats while the noradrenaline concentration in the A1-region was significantly elevated. No significant differences were found in both parameters in hypothalamic and medullary nuclei 3.5 weeks after the operation, when hypertension had fully developed. These findings are indicative of the occurrence of transient changes in the activity of noradrenergic neurons located in the medulla oblongata and projecting to the hypothalamus during the initiation of the development of two-kidney Goldblatt hypertension.
在肾性高血压大鼠（双肾Goldblatt高血压）的下丘脑和延髓的几个核团中，测定了去甲肾上腺素浓度以及α-甲基-对-酪氨酸（α-MPT）诱导的去甲肾上腺素消失情况。在肾动脉缩窄3天后，终纹床核间质核和室旁核中α-MPT诱导的去甲肾上腺素消失减少，此时血压略高于假手术大鼠，但差异显著。在此阶段，高血压大鼠的连合核和A1区中α-MPT诱导的去甲肾上腺素消失增强，而A1区的去甲肾上腺素浓度显著升高。术后3.5周，当高血压完全发展时，下丘脑和延髓核团的这两个参数均未发现显著差异。这些发现表明，在双肾Goldblatt高血压发生发展初期，位于延髓并投射到下丘脑的去甲肾上腺素能神经元的活动发生了短暂变化。
