Tanaka T, Seki A, Fujii J, Kurihara H, Ikeda M
Hypertension. 1982 Mar-Apr;4(2):272-8. doi: 10.1161/01.hyp.4.2.272.
To assess the role of the sympathetic and central noradrenergic neurons in one- and two- kidney Goldblatt hypertension, we examined the concentration and turnover of norepinephrine (NE) in the aorta, mesenteric artery, left ventricle, hypothalamus, midbrain, and pons medulla of hypertensive and control rabbits. Animals were made hypertensive by constriction of the left renal artery after right nephrectomy (1KGH group) or with the right kidney left intact (2KGH group), or were sham-operated on the renal artery (1KGC and 2KGC groups). At 14 days after the constriction, the blood pressure was increased to 136 +/- 3 mm Hg in the 1KGH vs 98 +/- 3 mm Hg in the 1KGC (p less than 0.001), and 136 +/- 2 mm Hg in the 2KGH vs 94 +/- 2 mm Hg in the 2KGC group (p less than 0.001). Turnover time in the aorta, mesenteric artery, and left ventricle in the 1KGH group was decreased to 47%, 45%, and 65% of that in the 1KGC group, respectively. Results suggest that enhanced sympathetic neuron activity in the cardiovascular system, especially in the arteries, contributes to the development of one-kidney Goldblatt hypertension. Norepinephrine turnover in the cardiovascular tissues in the 2KGH group and in the brain stem in the 1KGH and 2KGH group was not different from that in the control group.
为了评估交感神经和中枢去甲肾上腺素能神经元在一侧肾和双侧肾 Goldblatt 高血压中的作用，我们检测了高血压兔和对照兔的主动脉、肠系膜动脉、左心室、下丘脑、中脑以及脑桥延髓中去甲肾上腺素（NE）的浓度和周转率。通过右侧肾切除术后结扎左肾动脉使动物患高血压（1KGH 组），或保留右肾完整（2KGH 组），或对肾动脉进行假手术（1KGC 和 2KGC 组）。结扎后 14 天，1KGH 组血压升高至 136±3 mmHg，而 1KGC 组为 98±3 mmHg（p＜0.001）；2KGH 组血压为 136±2 mmHg，2KGC 组为 94±2 mmHg（p＜0.001）。1KGH 组主动脉、肠系膜动脉和左心室的周转率分别降至 1KGC 组的 47%、45%和 65%。结果表明，心血管系统尤其是动脉中交感神经元活性增强，有助于一侧肾 Goldblatt 高血压的发展。2KGH 组心血管组织以及 1KGH 和 2KGH 组脑干中的去甲肾上腺素周转率与对照组无差异。
