[Allergenic properties of a series of N-phenyl N'alcoyl paraphenylenediamines].

The well known high allergenic potential of N-phenyl N'-isopropyl paraphenylenediamine (I.P.P.D.), as well as that of N-phenyl N'-1,3 dimethylbutyl paraphenylenediamine, though allegedly milder, prompted us to investigate the allergenicity of a series of N-phenyl N'-alcoyl paraphenylenediamines. We chose an existing technical grade series with substituents ranging from methyl to dodecyl. The results, on laboratory animals (Kligman and Magnusson's maximalization test), and on I.P.P.D.-sensitized humans (ROC Neodermotest, 48th hour) indicate a group sensitization with nearly systematic cross-reactions.