Macklem P T
Fed Proc. 1980 Aug;39(10):2755-8.
Most equations proposed to describe pulmonary pressure-flow relationships are inadequate because the "constants" that contain the airway geometry are not, in fact, constant but vary as the distribution of Reynold's number Re varies with flow or gas density. However, even when the normalized pressure drop is plotted against Re (Moody diagram), different relationships are found for different gas mixtures. Thus the normalized pressure drop is a function of one or more variables in addition to Re. As long as this variable or variables remain unknown, the pulmonary pressure-flow relationships will remain paradoxical.
大多数用于描述肺压力-流量关系的方程并不完善,因为包含气道几何形状的“常数”实际上并非恒定不变,而是会随着雷诺数Re的分布随流量或气体密度的变化而变化。然而,即使将归一化压降与Re绘制在一起(穆迪图),对于不同的气体混合物也会发现不同的关系。因此,除了Re之外,归一化压降还是一个或多个变量的函数。只要这个或这些变量仍然未知,肺压力-流量关系就会仍然存在矛盾。