Green A S
Department of Mechanical and Design Engineering, University of Portsmouth, Anglesea Building, Anglesea Road, Portsmouth PO1 3DJ, UK.
J Biomech. 2004 May;37(5):661-7. doi: 10.1016/j.jbiomech.2003.09.024.
Some respiratory diseases result in the inflammation of the lung airway epithelium. An associated chronic cough, as found in many cases of asthma and in long-term smokers, can exacerbate damage to the epithelial layer. It has been proposed that wall shear stresses, created by peak expiratory flow-rates during a coughing episode, are responsible. The work here uses a computational fluid dynamics technique to model peak expiratory flow in the trachea and major lung bronchi. Calculated wall shear stress values are compared to a limited set of published measurements taken from a physical model. The measurements are discussed in the context of a flow study of a complex bronchial network. A more complete picture is achieved by the calculation method, indicating, in some cases, higher maximum wall shear stresses than measured, confirming the original findings of the experimental work. Recommendations are made as to where further work would be beneficial to medical applications.
一些呼吸系统疾病会导致肺气道上皮炎症。在许多哮喘病例和长期吸烟者中发现的相关慢性咳嗽，会加剧对上皮层的损害。有人提出，咳嗽发作期间的呼气峰值流速产生的壁面剪应力是造成这种情况的原因。本文利用计算流体动力学技术对气管和主要肺支气管中的呼气峰值流速进行建模。将计算得到的壁面剪应力值与从物理模型中获取的一组有限的已发表测量值进行比较。这些测量值是在对复杂支气管网络的流动研究背景下进行讨论的。通过计算方法获得了更完整的情况，表明在某些情况下，最大壁面剪应力比测量值更高，证实了实验工作的原始发现。针对进一步的工作在哪些方面对医学应用有益提出了建议。
