Eliasson R, Dornbusch K
Int J Androl. 1980 Jun;3(3):236-42. doi: 10.1111/j.1365-2605.1980.tb00113.x.
The concentration of metronidazole has been studied in blood and in seminal plasma from apparently healthy volunteers and men with subclinical prostatitis. The volunteers took one dose of 500 mg orally and the patients 250 mg twice daily for two to three days. Therapeutic concentrations of metronidazole were found in blood and semen two to three h after intake. In patients the mean concentration was 8.7 micrograms/ml in blood plasma and 7.0 micrograms/ml in seminal plasma. Split ejaculates were collected in four to six fractions and the concentrations of metronidazole in the different fractions were related to those for zinc and fructose. The results indicated that the drug was excreted from prostate, seminal vesicles, and the ampulla ductus deferens.
已对健康志愿者和亚临床前列腺炎男性的血液及精浆中的甲硝唑浓度进行了研究。志愿者口服一剂500毫克，患者每日两次、每次250毫克，持续两至三天。服药后两至三小时，在血液和精液中发现了治疗浓度的甲硝唑。患者血浆中甲硝唑的平均浓度为8.7微克/毫升，精浆中为7.0微克/毫升。射精样本分为四至六份收集，不同份中甲硝唑的浓度与锌和果糖的浓度相关。结果表明，该药物从前列腺、精囊和输精管壶腹排出。
