Humes H D, Dieppa R A, Brenner B M
Invest Urol. 1980 Jul;18(1):46-51.
Micropuncture and metabolic studies were performed using Sprague-Dawley rats with hereditary hydronephrosis secondary to vesicoureteric reflux. Whole kidney and single nephron glomerular filtration rates in hydronephrotic and nonhydronephrotic rats were essentially identical. Filtration rates were maintained near normal in hydronephrotic rats because of an elevation in the mean glomerular transcapillary hydraulic pressure difference which effectively offsets a lower initial glomerular capillary plasma flow rate and a possible decrease in the glomerular capillary ultrafiltration coefficient relative to nonhydronephrotic rats. Additional renal abnormalities, including a urinary concentrating defect, a renal sodium conserving defect, and calcium apatite nephrolithiasis, were also found in hydronephrotic rats.
对继发于膀胱输尿管反流的遗传性肾积水的斯普拉格-道利大鼠进行了微穿刺和代谢研究。肾积水大鼠和非肾积水大鼠的全肾和单肾单位肾小球滤过率基本相同。肾积水大鼠的滤过率维持在接近正常水平，这是因为平均肾小球跨毛细血管液压差升高，有效地抵消了较低的初始肾小球毛细血管血浆流速，以及相对于非肾积水大鼠而言肾小球毛细血管超滤系数可能的降低。在肾积水大鼠中还发现了其他肾脏异常，包括尿浓缩功能缺陷、肾钠潴留缺陷和钙磷灰石肾结石。
