Microencapsulated mitomycin C in transcatheter embolization of dog kidney.

Microencapsulated mitomycin C (MMC) was utilized for arterial embolization of dog kidneys. Renal damage was evaluated by angiographic and pathologic examinations. The most extensive embolic necrosis was associated with the use of microencapsulated MMC compared to blank microcapsules, nonencapsulated MMC, and a combination of both. Arterial infusion of microencapsulated MMC kept the concentration of MMC low in the circulating blood and sustained the biological potential of MMC in the kidney for prolonged periods of time as compared with nonencapsulated MMC. Transcatheter infusion of microencapsulated MMC could be clinically applied to the therapeutic arterial embolization of the tumor-supplying vessels together with regional anticancer chemotherapy.