Nemoto R, Kato T, Mori H, Harada M
Invest Urol. 1980 Jul;18(1):69-73.
Microencapsulated mitomycin C (MMC) was utilized for arterial embolization of dog kidneys. Renal damage was evaluated by angiographic and pathologic examinations. The most extensive embolic necrosis was associated with the use of microencapsulated MMC compared to blank microcapsules, nonencapsulated MMC, and a combination of both. Arterial infusion of microencapsulated MMC kept the concentration of MMC low in the circulating blood and sustained the biological potential of MMC in the kidney for prolonged periods of time as compared with nonencapsulated MMC. Transcatheter infusion of microencapsulated MMC could be clinically applied to the therapeutic arterial embolization of the tumor-supplying vessels together with regional anticancer chemotherapy.
微囊化丝裂霉素C（MMC）用于犬肾动脉栓塞。通过血管造影和病理检查评估肾损伤。与空白微囊、未包封的MMC以及两者组合相比，使用微囊化MMC导致的栓塞坏死最为广泛。与未包封的MMC相比，动脉内注入微囊化MMC可使循环血液中MMC的浓度保持较低，并能长时间维持MMC在肾脏中的生物学活性。经导管注入微囊化MMC可在临床应用于肿瘤供血血管的治疗性动脉栓塞以及区域抗癌化疗。
