Johansson G, Backman U, Danielson B G, Ljunghall S, Wikström B
Invest Urol. 1980 Sep;18(2):93-6.
Magnesium metabolism in 70 consecutive patients with renal stone disease was evaluated and compared with that of a control group matched for age and sex. Serum and urinary magnesium values were not different in the two groups, but magnesium output was greater in males than in females. Stone-formers excreted more calcium in their urine than did controls, and the urinary calcium and magnesium values for both groups were positively correlated. For both groups, the magnesium/calcium ratio in the urine declined with increasing calcium values but was lower in stone-formers than in controls for corresponding calcium values. Intestinal magnesium uptake was the same in both groups. Magnesium deficiency was not evident among stone-formers as assessed by the determination of the magnesium content in muscle specimens or by the retention of an intravenously administered magnesium load. Although stone-formers were not found to display any features of magnesium metabolism that were different from those in the control group, their lower urinary excretion of magnesium in relation to calcium may be a factor in their increased stone-forming propensity.
对70例连续性肾结石病患者的镁代谢进行了评估，并与年龄和性别相匹配的对照组进行了比较。两组的血清和尿镁值无差异，但男性的镁排出量高于女性。结石形成者尿中排出的钙比对照组多，且两组的尿钙和镁值呈正相关。两组的尿镁/钙比值均随钙值的增加而下降，但在相应钙值时，结石形成者的该比值低于对照组。两组的肠道镁摄取相同。通过测定肌肉标本中的镁含量或静脉注射镁负荷后的潴留情况评估，结石形成者中未发现明显的镁缺乏。尽管未发现结石形成者有任何与对照组不同的镁代谢特征，但他们尿中镁相对于钙的排泄较低可能是其结石形成倾向增加的一个因素。
