猕猴（恒河猴）孕期的甲胎蛋白值。

alpha-Fetoprotein values in monkey (Macaca mulatta) pregnancy.

作者信息

Ehrenkranz R A, Chez R A, Princler G L, McIntire K R, Waldmann T A

出版信息

Teratology. 1977 Dec;16(3):313-6. doi: 10.1002/tera.1420160310.

DOI:10.1002/tera.1420160310

Abstract

The pregnant rhesus monkey's (Macaca mulatta) potential as a model for understanding the dynamics of alpha-fetoprotein (AFP) metabolism in human pregnancy was evaluated. AFP levels in maternal and fetal serum and amniotic fluid were determined by radioimmunoassay. Significant correlations were found between decreasing maternal serum, fetal serum and amniotic fluid AFP concentrations and increasing gestational age. However, these data are not consistent with the AFP changes reported in human pregnancy. It appears that this animal has limited applicability as a model in this aspect of human pregnancy.

摘要

评估了怀孕恒河猴（猕猴属）作为理解人类妊娠中甲胎蛋白（AFP）代谢动态模型的潜力。通过放射免疫测定法测定母血、胎儿血清和羊水中的AFP水平。发现母血、胎儿血清和羊水AFP浓度降低与孕周增加之间存在显著相关性。然而，这些数据与人类妊娠中报道的AFP变化不一致。看来这种动物作为人类妊娠这方面的模型适用性有限。