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胎儿出血导致羊水甲胎蛋白(AFP)值的误判(作者译)

[Misinterpretation of alpha-fetoprotein (AFP) values in amniotic fluid due to fetal hemorrhage (author's transl)].

作者信息

Schumann K, Weitzel H

出版信息

Z Geburtshilfe Perinatol. 1978 Apr;182(2):98-104.

PMID:77588
Abstract

The AFP concentration in the amniotic fluid is elevated after contamination of the sample with fetal blood during a traumatic amniocentesis. Though the calculation of AFP due to fetal hemorrhage is possible by counting the fetal red cells there may be execssive errors resulting from the variability of fetal red cell count, amniotic volume, fetal serum AFP concentration, AFP concentration in the amniotic fluid changing with fetal age. Therefore it is impossible to interpretate elevated AFP values from a sample stained with fetal blood. A repeated amniocentesis is unavoidable. The correct time to do a second punction is still a matter of question.

摘要

在创伤性羊膜穿刺术期间样本被胎儿血液污染后,羊水中甲胎蛋白(AFP)浓度会升高。尽管通过计数胎儿红细胞来计算因胎儿出血导致的AFP是可行的,但由于胎儿红细胞计数、羊水量、胎儿血清AFP浓度以及羊水中AFP浓度随胎龄变化的差异,可能会产生过多误差。因此,无法解读被胎儿血液污染样本中升高的AFP值。重复进行羊膜穿刺术是不可避免的。进行第二次穿刺的正确时间仍然是个问题。

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