Tilbury R S, Myers W G, Chandra R, Dahl J R, Lee R
J Nucl Med. 1980 Sep;21(9):867-71.
A method is described for generating 20--30 mCi of 7.6-min potassium-38 by means of a small cyclotron. Sodium chloride is mounted on a water-cooled tantalum plate, by evaporation from an aqueous solution. It is bombarded with 14.7 MeV helium-4 ions, at 50 microA. The K-38 is produced free of other radionuclides. For intravenous injection the bombarded NaCl is dissolved in sufficient pyrogen-free water to make an isotonic saline solution, which then is sterilized by filtration. Other methods of production investigated were the bombardment of: carbon tetrachloride with He-4 ions; calcium oxide with 7.8-MeV deuterons; and potassium chloride with 23-MeV He-3 ions. These gave products that were unsuitable for clinical applications. Chiefly because of the short half-life of K-38, the whole-body radiation exposure is estimated to be only about 12 mrad/mCi, and exposures to the heart and kidneys are approximately ten times greater.
描述了一种利用小型回旋加速器生成20 - 30毫居里7.6分钟半衰期的钾 - 38的方法。氯化钠通过从水溶液中蒸发而附着在水冷钽板上。用50微安的14.7兆电子伏特氦 - 4离子对其进行轰击。生成的钾 - 38不含有其他放射性核素。用于静脉注射时，将被轰击的氯化钠溶解在足够量的无热原水中制成等渗盐溶液，然后通过过滤进行灭菌。研究的其他生产方法包括：用氦 - 4离子轰击四氯化碳；用7.8兆电子伏特氘核轰击氧化钙；以及用23兆电子伏特氦 - 3离子轰击氯化钾。这些方法得到的产物不适合临床应用。主要由于钾 - 38的半衰期短，全身辐射暴露估计仅约为12毫拉德/毫居里，而心脏和肾脏的暴露量大约是其十倍。
