Effect of voluntary exercise and dietary protein levels on the activity of serum glutamic pyruvic transaminase and the morphological picture of liver in mice.

In the present investigation, effects of voluntary exercise on serum glutamic pyruvic transaminase (SGPT) activity and histological alterations of liver tissue of mice fed 4%, 6% and 20% casein diet were examined. AGPT activity showed decreasing values accompanied by dietary protein level increases. In 4% casein diet groups, SGPT activity of the exercise group was markedly lower than that of the non-exercise group. Furthermore, there was a negative correlation between SGPT and LCAT activity. In histological evaluation, the non-exercise group on 4% casein diet revealed diffuse fatty degeneration of the liver, but the exercise group did not show such changes.