Katoh M, Kitada M, Satoh T, Kitagawa H, Sugimoto T, Kasai T
J Pharmacobiodyn. 1980 May;3(5):261-3. doi: 10.1248/bpb1978.3.261.
Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the components of rat liver microsomal electron transport system was investigated by comparison with those of phenobarbital, 3-methylcholanthrene and polychlorinated biphenyl. When NKK-105 was administered to rats at a dose of 250 mg/kg/day for 7 days, cytochrome b5 content and NADPH-cytochrome c reductase activity were significantly increased but cytochrome P-450 content to the lesser extent. Three inducers of the drug metabolizing enzymes remarkably increased cytochrome P-450 content but increased cytochrome b5 content to a lesser extent.
通过与苯巴比妥、3-甲基胆蒽和多氯联苯相比较，研究了丙二酸1,3-二硫代-2-亚丙酯（NKK-105）对大鼠肝脏微粒体电子传递系统各组分的影响。当以250mg/kg/天的剂量给大鼠施用NKK-105，持续7天时，细胞色素b5含量和NADPH-细胞色素c还原酶活性显著增加，但细胞色素P-450含量增加程度较小。三种药物代谢酶诱导剂显著增加细胞色素P-450含量，但细胞色素b5含量增加程度较小。
